Liver Cirrhosis can cause widespread damage for patients, including deposits of manganese, a trace mineral, which can affect the brain. Manganese is a key mineral used by our bodies for a variety of chemical processes, including the metabolism of cholesterol and carbohydrates, but people only need it in small amounts. The HMRI research team, including Neurosciences Scientific Director Michael Harrington, MD, showed that damage from liver cirrhosis gives an altered signal intensity consistent with increased manganese deposition on MRI, which was not found in healthy controls. This method may help quantify and track treatment in patients with cirrhosis.
Title: MRI Automated T1 Signal Intensity Detection of Diffuse Brain Manganese Accumulation in Cirrhosis
By: Journal of NeuroImaging
Author: Ke Wei , Thao T. Tran, Patrick W. Chang, Annie Malekie, Karen Chu, Lea Alhilali, Matthew T. Borzage, Edward Mena, Michael G. Harrington, and Kevin S. King
Date: Jan/Feb 2021